What I use most of the time:
Laser RCW + Recycler
I converted all my ammo into over charge ammo so it's pretty powerful despite my energy weapons skill being in the low 30s.
Maria
It's a stronger 9mm pistol you get from Benny. I was sad when I found out I couldn't use 9mm pistol mods on it but whatever.
Cowboy Repeater
This thing is so fucking powerful that there's no reason not to use it.
Assault Carbine + Extended Magazine
I only use armor-piercing ammo with this piece of shit because it's so weak without it. It's basically outclassed by my Laser RCW and ammo is harder to come by so I hardly use it any more.
Varmint Rifle + Night Scope + Silencer + Extended Magazine
You would think that with all those mods they would at least include one that makes the weapon not suck. It does less damage than my pistol so I only use it to get sneak attacks on really weak enemies.
Anti-Materiel Rifle
Armor piercing ammo all the fucking way. Whenever I find an enemy that's too strong for my other weapons I pull this bad boy out and send them straight to hell.
Laser RCW + Recycler
I converted all my ammo into over charge ammo so it's pretty powerful despite my energy weapons skill being in the low 30s.
Maria
It's a stronger 9mm pistol you get from Benny. I was sad when I found out I couldn't use 9mm pistol mods on it but whatever.
Cowboy Repeater
This thing is so fucking powerful that there's no reason not to use it.
Assault Carbine + Extended Magazine
I only use armor-piercing ammo with this piece of shit because it's so weak without it. It's basically outclassed by my Laser RCW and ammo is harder to come by so I hardly use it any more.
Varmint Rifle + Night Scope + Silencer + Extended Magazine
You would think that with all those mods they would at least include one that makes the weapon not suck. It does less damage than my pistol so I only use it to get sneak attacks on really weak enemies.
Anti-Materiel Rifle
Armor piercing ammo all the fucking way. Whenever I find an enemy that's too strong for my other weapons I pull this bad boy out and send them straight to hell.